Characterization of diethylnitrosamine-induced liver carcinogenesis in Syrian golden hamsters
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Emodin Downregulates Cell Proliferation Markers during Dmba Induced Oral Carcinogenesis in Golden Syrian Hamsters
BACKGROUND Cell-cycle disruption is the major characteristic features of neoplastic transformation and the status of cell-cycle regulators can thus be utilized to assess the prognostic significance in patients with cancer. The PCNA, cyclin D1, CDK4, CDK6 and survivin expression in the buccal mucosa was utilized to evaluate the Emodin efficacy on abnormal cell proliferation during 7,12-dimethylb...
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Ultrastructural observations by scanning electron microscope (SEM) of preor neoplastic tracheal lesions in Syrian golden hamsters induced by diethylnitrosamine (DEN) were investigated. Twenty five, six-week-old, male Syrian golden hamsters were injected subcutaneously twice a week for 12 weeks with 18mg/kg body weight of DEN. Six hamsters were injected only vehicle and served as control. At wee...
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Six homologous nitrosomethyl-n-alkylamines, from n-propyl (C-3) to n-octyl (C-8), were administered by gavage to groups of 12 male and 12 female Syrian golden hamsters as solutions in corn oil:ethyl acetate (2:1). The solutions of C-8 to C-4 were equimolar; nitrosomethyl-n-butylamine (C-4) and nitrosomethyl-n-propylamine (C-3) were given at a lower concentration. Treatment with 0.2 ml of soluti...
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The N(6)-cyclohexyladenosine (CHA)-induced hypothermia in Syrian hamsters was characterized as follows: intracerebroventricular injection of CHA-induced hypothermia and the potency was increased by lowering the ambient temperature. CHA microinjection into the anterior hypothalamus (AH) elicited the most marked body temperature (T(b)) decrease compared with other regions such as the preoptic are...
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ژورنال
عنوان ژورنال: Experimental and Therapeutic Medicine
سال: 2011
ISSN: 1792-0981,1792-1015
DOI: 10.3892/etm.2011.406